Therapeutic Targeting of Signal Transduction Pathways and Proteins in Breast Cancer
نویسندگان
چکیده
منابع مشابه
Signal Transduction Pathways in Breast Cancer – Drug Targets and Challenges
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in females worldwide [1]. Over 1.1 million cases of breast cancer are diagnosed across the world each year, compared with about 500,000 cases in 1975. This represents about 10% of all new cancer cases and 23% of all female cancers [2-3]. An annual prevalence of more than 4.4 million cases of breast cance...
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Greater understanding of the underlying etiology and biology of breast cancer is enabling the clinical development of targeted therapies for metastatic breast cancer (MBC). Following the successful introduction of trastuzumab, the first human epidermal growth factor receptor (HER) biologically targeted therapy to become widely used in MBC patients, other agents have been developed. Novel agents...
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In this era of systems biology, the tide of information derived from "omic" technologies (genomics, proteomics, etc.) has sparked a revolution in drug design, with many industrial and academic programs now embracing the concepts of molecular medicine (i.e., targeting changes in specific proteins or pathways) as measures of treatment efficacy and outcome. This approach has yielded a plethora of ...
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ژورنال
عنوان ژورنال: Journal of Mammary Gland Biology and Neoplasia
سال: 2006
ISSN: 1083-3021,1573-7039
DOI: 10.1007/s10911-006-9007-3